According to our social science, we can be or become wise in all matters of secondary importance, but we have to be resigned to utter ignorance in the most important respect: we cannot have any knowledge regarding the ultimate principles of our choices, i. e. regarding their soundness or unsoundness... We are then in the position of beings who are sane and sober when engaged in trivial business and who gamble like madmen when confronted with serious issues.

p. 4 - Natural Right and History (1953)