American Mathematician Quotes
Molecular dynamics is not primarily about making movies of molecules. More often it is about developing quantitative predictions of molecular size and shape, flexibilities, interactions with other molecules, behavior under pressure, and the relative frequency of one state or conformation compared to another.
Mathematics must take its motivation from concrete specific substance and aim again at some layer of "reality." The flight into abstraction must be something more than a mere escape; start from the ground and reentry are both indispensable, even if the same pilot cannot handle all phases of the trajectory.
Mathematics is not the discoverer of laws, for it is not induction; neither is it the framer of theories, for it is not hypothesis; but it is the judge over both, and it is the arbiter to which each must refer its claims; and neither law can rule nor theory explain without the sanction of mathematics.
George Boole took up Leibniz's idea, and wrote a book he called The Laws of Thought. The laws he formulated are now called Boolean algebra... Boole seems to have had a grandiose vision about the applicability of his algebraic methods to practical problems—his book makes it clear that he hoped these laws would be used to settle practical questions. William Stanley Jevons heard of Boole's work, and undertook to build a machine to make calculations in Boolean algebra. He successfully designed and built... the Logical Piano... the first machine to do mechanical inference.
[The George E. P. Box paper Fitting empirical data (1960) is] a mature exposition of an important branch of statistics, to which the author has made great contributions. One feature of particular interest is practical discussion of genuinely nonlinear fitting problems and their solution with the help of tact and a special, publicly available, IBM-704 program. Another is insightful comments on the role of prior distributions in statistics.