Misleading may be the claims that procedures [of animal testing] are carried out under anaesthesia. Restraining devices and paralysing drugs can today be so effective that an anaesthetic is often unnecessary from the purely practical point of view. The risk of giving a dose too large and thereby losing an expensive chimpanzee, for example, may often tempt a scientist or technician, inexperienced with sophisticated anaesthetic techniques, to give a dose too small, from which the animal quickly recovers — but not of course until after it has been strapped securely to the operating table.

Experiments on Animals (1971)