Two main lines are readily distinguished. One already well developed in the hands of von Bertalanffy and his co-workers, takes the world as we find it, examines the various systems that occur in it - zoological, physiological, and so on - and then draws up statements about the regularities that have been observed to hold. This method is essentially empirical. The second method is to start at the other end. Instead of studying first one system, then a second, then a third, and so on, it goes to the other extreme, considers the set of all conceivable systems and then reduces the set to a more reasonable size. This is the method I have recently followed.

Ashby (1958) "General Systems Theory as a new Discipline". General Systems, 3 (1958). p. 1-6; cited in: Ludwig von Bertalanffy (1968) General System Theory. p. 94-95