The contradictory experiments of chemists leave us at liberty to conclude what we please. My conclusion is, that art has not yet invented sufficient aids to enable such subtle bodies [air, light, &c.] to make a well-defined impression on organs as blunt as ours; that it is laudable to encourage investigation but to hold back conclusion.

Memoir, correspondence, and miscellanies from the papers of T. Jefferson (ed. 1829)