It is with philosophy as with just intonation on a piano, if you get everything quite straight and on all fours in one department, in perfect tune, it is delightful so long as you keep well in the middle of the key; but as soon as you modulate you find the new key is out of tune and the more remotely you modulate the more out of tune you get.
Philosophy and Equal Temperament - The Note-Books of Samuel Butler (1912) - Part XX - First Principles