The chance is high that the truth lies in the fashionable direction. But, on the off-chance that it is in another direction — a direction obvious from an unfashionable view of field theory — who will find it? Only someone who has sacrificed himself by teaching himself quantum electrodynamics from a peculiar and unfashionable point of view; one that he may have to invent for himself.

"The Development of the Space-Time View of Quantum Electrodynamics," Nobel Lecture (11 December 1965)

Richard P. Feynman - Nobel Lecture: The Development of the Space-Time View of Quantum Electrodynamics