The Noble Truth of Suffering is this: Birth is suffering, ageing is suffering; sickness is suffering; death is suffering; sorrow and lamentation, pain, grief and despair are suffering; association with the unpleasant is suffering; dissociation from the pleasant is suffering; not to get what one wants is suffering—in brief, the five aggregates of attachment are suffering.
First Sermon of the Buddha
Samyutta-nikāya [Kindred Sayings] pt. 56, p. 11