There is nothing that we call the symptom of a disease, which does not contain within itself much more than a mere sign. Heat, pain, redness, swelling, are called the signs of inflammation; but nature does not intend by them barely to intimate that inflammation exists; they are essentially connected with the processes she is carrying on.
Lectures on Subjects Connected With Clinical Medicine, Lecture VI (p. 143), Longman, Rees, Orme, Brown, Green & Longman. 1836