If one wanted to make a work of art devoid of meaning, it would be impossible because we've already given meaning to the work by indicating that it's a work of art.
Joseph Kosuth, Introduction in Art After Philosophy and After: Collected Writings, 1960–1990 (Cambridge: MIT Press, 1991); cited in: Thierry Mortier. "Semiotics as Art: Kosuth," Sunday, 1 July 2012.