The basis of tragedy is man's helplessness against disease, war and death; the basis of comedy is man's helplessness against vanity (the vanity of love, greed, lust, power).
Bio: John Heminges was an actor in the King's Men, the playing company for which William Shakespeare wrote. Along with Henry Condell, he was an editor of the First Folio, the collected plays of Shakespeare, published in 1623.