The basis of tragedy is man's helplessness against disease, war and death; the basis of comedy is man's helplessness against vanity (the vanity of love, greed, lust, power).
Bio: Jacobus Henricus van 't Hoff, Jr. was a Dutch physical and organic chemist and the first winner of the Nobel Prize in Chemistry. He is best known for his discoveries in chemical kinetics, chemical equilibrium, osmotic pressure, and stereochemistry.