An autopoietic machine is a machine organized (defined as a unity) as a network of processes of production (transformation and destruction) of components which:
(i) through their interactions and transformations continuously regenerate and realize the network of processes (relations) that produced them; and
(ii) constitute it (the machine) as a concrete unity in space in which they (the components) exist by specifying the topological domain of its realization as such a network.

p. 87. - Autopoiesis and cognition: The realization of the living (1980)