Whether or not science can be applied to that mental construct [i.e. the designed entity] is a matter of availability. If there is body of scientific knowledge that can be applied, then it would be foolish not to exploit it. However, if there is none, it does not mean that the thing cannot be designed, made, and used safely.

Small Things Considered: Why There is No Perfect Design (ed. Vintage, 2004) - ISBN: 9781400032938