Life cannot have had a random beginning … The trouble is that there are about two thousand enzymes, and the chance of obtaining them all in a random trial is only one part in 1040,000, an outrageously small probability that could not be faced even if the whole universe consisted of organic soup.

Fred Hoyle and N. Chandra Wickramasinghe, Evolution from Space (London: J.M. Dent & Sons, 1981)