In electron microscopy, the difficulties took considerably more time to surmount, and therefore the doubters held the field for a longer period. I can, however, also confirm from my own experience the observation of my colleagues that the doubt of the others has the advantage of leaving the field uncrowded. Mostly, this is understood only much later, in the beginning one is very disappointed.

On the advantage of facing doubt when one has discovered something new. Speech at the Nobel Banquet, December 10, 1986.

Ernst Ruska - Banquet Speech