Charles Scott Sherrington - The Integrative Action of the Nervous System (1906)

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If we denote excitation as an end-effect by the sign plus (+), and inhibition as end-effect by the sign minus (−), such a reflex as the scratch-reflex can be termed a reflex of double-sign, for it develops excitatory end-effect and then inhibitory end-effect even during the duration of the exciting stimulus.

Charles Scott Sherrington

That our being should consist of two fundamental elements [physical and psychical] offers I suppose no greater inherent improbability than that it should rest on one only.

Charles Scott Sherrington

This integrative action in virtue of which the nervous system unifies from separate organs an animal possessing solidarity, an individual, is the problem before us.

Charles Scott Sherrington

With the nervous system intact the reactions of the various parts of that system, the 'simple reflexes', are ever combined into great unitary harmonies, actions which in their sequence one upon another constitute in their continuity what may be termed the 'behaviour'

Charles Scott Sherrington

Each waking day is a stage dominated for good or ill, comedy, farce, or tragedy, by a dramatis personae, the 'self', and so it will be until the curtain drops.

Charles Scott Sherrington