It must afford no small pleasure to a benevolent mind in the midst of a war, which daily makes so much havoc with the human species, to reflect, that the small-pox which once proved equally fatal to thousands, has been checked in its career, and in a great degree subdued by the practice of Inoculation.

Rush, Benjamin (1792). The New Method of Inoculating for the Small-Pox. Philadelphia: Parry Hall.